I-Tacrolimus
I-Tacrolimus
I-Anhydrous evela ku-tacrolimus, i-macrolide ehlukanisiwe ne-Streptomyces tsukubaensis.I-Tacrolimus ibophezela kuphrotheni ye-FKBP-12 futhi yakhe inkimbinkimbi enamaprotheni ancike ku-calcium, ngaleyo ndlela ivimbele umsebenzi we-calcineurin phosphatase futhi okuholela ekwehleni kokukhiqizwa kwe-cytokine.
Ukuze isetshenziswe ngemva allogenic isitho ukufakelwa ukuze kuncishiswe umsebenzi amasosha omzimba esiguli futhi kanjalo ingozi ukulahlwa isitho.Ibuye isetshenziselwe ukulungiswa kwe-topical ekwelapheni i-atopic dermatitis enzima.
| Izinto | Imininingwane | Imiphumela |
| Ukubukeka | Impushana emhlophe ecwebezelayo | Kuyavumelana |
|
Ukuhlonza | Isikhathi sokugcinwa sesiqongo esikhulu sokulungiselelwa kwe-Assay sihambisana naleso sechromatogram yokulungiselelwa Okujwayelekile etholwe njengoba kuqondiswe ku-Assay. |
Kuyavumelana |
| [α] D23,.nge-chloroform | -75.0～ - 90.0º | -84.0º |
| Ibanga lokuncibilika | 122～129℃ | 125～128.0℃ |
| Amanzi | ≤3.0% | 1.9% |
| Izinsimbi Ezisindayo | ≤10ppm | Kuyavumelana |
| Izinsalela ekushiseni | ≤0.1% | Kuyavumelana |
| Izinto ezihlobene | Ukungcola okuphelele≤2.0% | 0.5% |
| Isivivinyo | ≥98.0% | 98.6% |
| Izinto | Imininingwane | Imiphumela |
| Ukubukeka | Impushana emhlophe ecwebezelayo | Kuyavumelana |
|
Ukuhlonza | Isikhathi sokugcinwa sesiqongo esikhulu sokulungiselelwa kwe-Assay sihambisana naleso sechromatogram yokulungiselelwa Okujwayelekile etholwe njengoba kuqondiswe ku-Assay. |
Kuyavumelana |
| [α]D23,.nge-chloroform | -75.0º～ - 90.0º | -84.0º |
| Ibanga lokuncibilika | 122～129℃ | 125～128.0℃ |
| Amanzi | ≤3.0% | 1.9% |
| Izinsimbi Ezisindayo | ≤10ppm | Kuyavumelana |
| Izinsalela ekushiseni | ≤0.1% | Kuyavumelana |
| Izinto ezihlobene | Ukungcola okuphelele ≤2.0% | 0.5% |
| Isivivinyo | ≥98.0% | 98.6% |
Isitoreji: endaweni eyomile, epholile, nenomthunzi enezinto ezipakishwayo zangempela, gwema umswakama, gcina ekamelweni lokushisa.
I-Shelf Life: izinyanga ezingu-48
Iphakheji:in25kg/isikhwama
ukulethwa: ngokushesha
1. Ithini imigomo yakho yokukhokha?
T/T noma L/C.
2. Yisiphi isikhathi sakho sokulethwa?
Ngokuvamile sizohlela ukuthunyelwa ezinsukwini ezingu-7 -15.
3. Kuthiwani ngokupakisha?
Ngokuvamile sinikeza ukupakisha njengoba 25 kg / isikhwama noma ibhokisi.Yebo, uma unezidingo ezikhethekile kuzo, sizokwenza ngokusho kwakho.
4. Kuthiwani ngokuba semthethweni kwemikhiqizo?
Ngokwemikhiqizo oyi-odile.
5. Yiziphi izincwadi ozinikezayo?
Ngokuvamile, sihlinzeka nge-invoyisi Yezohwebo, Uhlu Lokupakisha, Isikweletu Sokulayisha, i-COA, Isitifiketi Sezempilo kanye nesitifiketi Somsuka.Uma izimakethe zakho zinezidingo ezikhethekile, sazise.
6. Yini imbobo yokulayisha?
Ngokuvamile iShanghai, iQingdao noma iTianjin.
